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50th ERA-EDTA Congress

 

May 18-21 2013 Istanbul
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Discussion forum - 50th ERA-EDTA Congress
    Topic - AKI - experimental models

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Poster: 68
Visits: 61
Title: MITOCHONDRIA-TARGETED APPROACHES TO PREVENT GENTAMYCIN TOXICITY
Authors: Stanislovas Jankauskas , Irina B Pevzner, Ljubava D Zorova, Valentina A Babenko, Maria A Morosanova, Egor Y Plotnikov, Dmitry B Zorov
Centre: Faculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University

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MITOCHONDRIA-TARGETED APPROACHES TO PREVENT GENTAMYCIN TOXICITY

Stanislovas Jankauskas
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Reg: 4/24/2013 4:36:00 PM
Comment# 1
The toxic effects of aminoglycoside antibiotics are realized via stimulating intercellular reactive oxygen species (ROS) overproduction. Oxidative damage of mitochondria results in the opening of mitochondrial permeability transition pore (MPTP). The signaling prevents opening of MPTP are know as preconditioning (PC) phenomenon. PC signaling pathways are converged on glycogen synthase kinase 3&946; (GSK3&946;) and results in its inhibition by phosporylation.The aim of the study was to investigate whether mitochondria-targeted antioxidant SkQR1 and &61540;-opyoid receptor agonist (dalargin) and GSK3&946; inhibitor (LiCl) are able to prevent gentamycin toxicity.

Comment added on 4/24/2013 4:36:00 PM 
     
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Most viewed poster for this congress
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Title: EFFECTS OF UREMIC TOXIN P-CRESOL ON PROLIFERATION, APOPTOSIS, DIFFERENTIATION AND GLUCOSE UPTAKE IN 3T3-L1 CELLS
Authors: Sayuri Tanaka , Sayuri Tanaka,1 Shozo Yano,2 Toshitsugu Sugimoto.1
Centre: Shimane University Faculty of Medicine

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Title: INHIBITION OF OXIDATIVE STRESS DOES NOT PREVENT RENAL TUBULAR CYTOTOXICITY INDUCED BY CISPLATIN
Authors: Jose M. Lopez-Novoa , Sandra M Sancho-Martinez,1,2 Laura Prieto-Garcia,1 Francisco J Lopez-Hernandez,1,2,3 Jose M Lopez-Novoa.1,2
Centre: University of Salamanca


 






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